ea0015s11 | New twists in appetite/satiety signalling pathways | SFEBES2008
Heisler L
The central serotonin (5-hydroxytryptamine, 5-HT) system is an established modulator of ingestive behaviour. Pharmacological and genetic research implicates the serotonin 2C receptor (5-HT2CR) specifically in these effects. New selective 5-HT2CR agonists are being pursued for the treatment of human obesity. We sought to clarify how serotonin in general and the 5-HT2CR in particular modulate ingestive behaviour. The hypothalamus is a key brain r...